CAS: 109-99-9
Tetrahydrofuran (THF) is a highly adaptable, colorless organic compound widely used as a solvent. First discovered in the 1930s, it initially found use in synthetic rubber production during World War II. What sets THF apart from other solvents is its classification as a heterocyclic compound, meaning its molecular structure contains a ring composed of different elements—in this case, oxygen and carbon atoms. This unique structure allows THF to effectively dissolve both polar and nonpolar compounds, making it indispensable in various industrial applications today, particularly in the pharmaceutical sector.
Tetrahydrofuran is also used in the production of some specialty plastics, including the high-performance polymer poly(tetramethylene terephthalate) (PTT), known for its durability and elasticity.
Chemical Properties of Tetrahydrofuran (THF)
CAS: 109-99-9
Molecular Formula: C4H8O
Molar Mass: 72.11 g/mol
Boiling Point: 65 °C @ Press: 760 Torr
Melting Point: -108.3°C
Color (APHA): Max. 10
Density: 0.8892 g/cm³ at 20°C
Physical Properties
THF is a flammable liquid with an ether-like odor and is miscible with water and organic solvents. Its low viscosity and volatility make it ideal for applications requiring quick evaporation and efficient solvation.
THF in the Pharma Segment
In the pharmaceutical industry, THF is crucial for synthesizing active pharmaceutical ingredients (APIs) and creating polymer-based drug delivery systems. It also supports the production of coatings and chemical intermediates vital in drug formulation processes.
Across Other Industries
THF plays a significant role in various sectors:
Agriculture: Used in synthesizing herbicides and agrochemicals.
Construction: Supports the development of adhesives and protective coatings.
CASE (Coatings, Adhesives, Sealants, Elastomers): Used in the production of polyurethane coatings.
HI&I: Found in industrial and household cleaning products.
Plastics & Rubber: Essential for manufacturing polytetramethylene ether glycol (PTMEG) used in elastomers.
Oil & Gas: Utilized as a solvent in extraction processes and fluid formulations.