CAS: 25322-68-3
PEG 400 NF, or polyethylene glycol 400, is a low molecular weight polymer that belongs to the family of polyethylene glycols. It is distinguished from other compounds in its category by its unique combination of properties, including solubility in both water and organic solvents, making it particularly useful across various applications. PEG 400 has gained importance in the pharmaceutical industry due to its ability to enhance drug solubility and bioavailability. Historically, it has been utilized in numerous formulations, including ointments, creams, and oral medications, making it a significant ingredient in pharmaceutical manufacturing.
PEG 400 is commonly used as a lubricant in medical devices, like catheters and contact lenses, due to its smooth texture and biocompatibility.
Chemical Properties of PEG 400 NF:
CAS Number: 25322-68-3
Molecular Formula: H(OCH2CH2)nOH
Water Weight %: Max. 0.5
PH: Min. 4.5 , Max. 7.5
Physical Properties:
Appearance: Clear, viscous liquid
Odor: Characteristically odorless
Texture: Smooth and slippery
Color: Colorless to pale yellow
Melting Point: Liquid at room temperature, with a melting point of -66 °C
Boiling Point: High boiling point around 290 °C
Solubility: Completely soluble in water and a variety of organic solvents
Applications in the Pharma Segment
In the pharmaceutical industry, PEG 400 serves multiple roles. It is primarily used as a solvent for drugs, enhancing their solubility and stability. Additionally, it acts as a base in various topical formulations, providing moisture and improving the texture of creams and ointments. Its biocompatibility makes it suitable for drug delivery systems, enabling controlled release of medications.Other Industries
Agriculture: Utilized as a surfactant in pesticide formulations.
Food and Nutrition: Employed as a food additive for its thickening and emulsifying properties.
Personal Care: Acts as a moisturizer in lotions and cosmetics.
Construction: Used in adhesives and sealants due to its flexible properties.
CASE (Coatings, Adhesives, Sealants, Elastomers): Functions as a plasticizer in various formulations.
HI&I (Household, Industry and Institutions): Incorporated in cleaning agents for its solvency and emulsification abilities.
Lubricants and Greases: Provides viscosity and stability in formulations.
Petroleum and Gas: Serves as a demulsifier in oil-water separation processes.
Plastic and Rubber: Used in the production of flexible polymers.